{"id":132883,"date":"2022-05-23T14:38:03","date_gmt":"2022-05-23T05:38:03","guid":{"rendered":"http:\/\/192.249.19.202\/?post_type=ai-in-signal&#038;p=132883"},"modified":"2026-04-07T10:53:28","modified_gmt":"2026-04-07T01:53:28","slug":"ee-professor-yoon-young-gyu-and-joint-research-team-develop-high-performance-simultaneous-detector-of-multiple-markers-in-tissues","status":"publish","type":"ai-in-signal","link":"http:\/\/ee.presscat.kr\/en\/ai-in-signal\/ee-professor-yoon-young-gyu-and-joint-research-team-develop-high-performance-simultaneous-detector-of-multiple-markers-in-tissues\/","title":{"rendered":"EE Professor Yoon, Young-Gyu and Joint Research Team Develop High-performance Simultaneous Detector of Multiple Markers in Tissues"},"content":{"rendered":"<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-full wp-image-131180\" src=\"http:\/\/ee.presscat.kr\/wp-content\/uploads\/2022\/05\/\uc5f0\uad6c\uc9c4\uc0ac\uc9c4_\ucea1\ucc98.png\" alt=\"\" width=\"389\" height=\"146\" title=\"\" srcset=\"http:\/\/ee.presscat.kr\/wp-content\/uploads\/2022\/05\/\uc5f0\uad6c\uc9c4\uc0ac\uc9c4_\ucea1\ucc98.png 389w, http:\/\/ee.presscat.kr\/wp-content\/uploads\/2022\/05\/\uc5f0\uad6c\uc9c4\uc0ac\uc9c4_\ucea1\ucc98-300x113.png 300w\" sizes=\"(max-width: 389px) 100vw, 389px\" \/><\/p>\n<p><span style=\"font-family: verdana, geneva, sans-serif;font-size: 8pt\">[Prof. Yoon, Young-Gyu, Kim, Jeewon (PH.D candidate), Prof. Chang, Jae-Byum From Left: ]<\/span><\/p>\n<div><span style=\"font-family: verdana, geneva, sans-serif\">KAIST EE Professor Yoon, Young-Gyu\u2019s and Materials Science and Engineering Professor Chang, Jae-Byum\u2019s team conducted a joint research published as PICASSO, a simultaneous detector of multiple markers capable of capturing five times as many protein markers in comparison with existing techniques.<\/span><\/div>\n<p><span style=\"font-family: verdana, geneva, sans-serif\">Recent studies have shown that protein markers in the cancer tissues manifest differently across cancer patients. Related research findings indicate that such a difference determines the cancer progress as well as reactivity to anti-cancer drugs. This is why detecting multiple markers, also known as multiplexed imaging, from cancer tissues is deemed essential.<\/span><\/p>\n<p><span style=\"font-family: verdana, geneva, sans-serif\">The research team\u2019s development, PICASSO, is capable of detecting 15\u00a0\u2013\u00a0and at most 20\u00a0\u2013\u00a0protein markers at once via fluorescence imaging. This development was made possible by utilizing fluorophores exhibiting similar emission spectra simultaneously and accurately isolating each type of the fluorophores with blind source separation. Said technique does not require specialized reagent or expensive equipment and is thus considered a promising method of better diagnosis of cancer and drug development as well as protein marker discovery.<\/span><\/p>\n<p><span style=\"font-family: verdana, geneva, sans-serif\">EE\u00a0PH.D student\u00a0Kim, Jeewon and Materials Science and Engineering student Seo, Junyoung, and alumnus Sim, Yeonbo have led the research as first authors, and their paper was published in Nature Communications, book 13, May as \u201cPICASSO allows ultra-multiplexed fluorescence imaging of spatially overlapping proteins without reference spectra measurement\u201d.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" class=\"alignnone size-full wp-image-131182\" src=\"http:\/\/ee.presscat.kr\/wp-content\/uploads\/2022\/05\/image01_Marker_reserch.png\" alt=\"\" width=\"563\" height=\"190\" title=\"\" srcset=\"http:\/\/ee.presscat.kr\/wp-content\/uploads\/2022\/05\/image01_Marker_reserch.png 563w, http:\/\/ee.presscat.kr\/wp-content\/uploads\/2022\/05\/image01_Marker_reserch-300x101.png 300w\" sizes=\"(max-width: 563px) 100vw, 563px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>623<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-132883","ai-in-signal","type-ai-in-signal","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"http:\/\/ee.presscat.kr\/en\/wp-json\/wp\/v2\/ai-in-signal\/132883","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/ee.presscat.kr\/en\/wp-json\/wp\/v2\/ai-in-signal"}],"about":[{"href":"http:\/\/ee.presscat.kr\/en\/wp-json\/wp\/v2\/types\/ai-in-signal"}],"wp:attachment":[{"href":"http:\/\/ee.presscat.kr\/en\/wp-json\/wp\/v2\/media?parent=132883"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}